Our personal genome-wide testing service offers a full look at your genetic predisposition to infectious diseases as well as a detailed report on the strength of your auto-immune system, as it specifically relates to most virus types.

 

Why some individuals resist infection or recover quickly, whereas other experience severe disease associated with infection, and which group are you in, is a fundamental question of primary utility in today's world. That DNA is an important - if not the primary - factor that determines how an individual responds to infectious diseases, no longer surprises anyone.

scientific details, how do we know?

Albright et al. [1] estimated the risk of death for relatives of 4855 individuals spanning three generations in an effort to identify a genetic link for influenza, taking into account the pandemics of 1918 and 1932. It was found that individuals having a relative who died of influenza during the first pandemic where almost twice as likely as the average to die from influenza themselves during the second pandemic, suggesting a strong link between genetic heredity and resistance to influenza.

Since then, a wealth of knowledge has been accumulated in this area, as you will see by reading below. What will your genetic results contain?

 

Genetic polymorphism related to your immune system

We look at the primary genes responsible for the normal operation of your immune system.

 

in detail
Toll-like receptors (TLR), particularly TLR3 and ISG15 ubiquitin-like modifier are central to antiviral innate immunity. These genes regulate and recognizes DNA and RNA, the coding material of viruses. The TNF gene, also known as TNF-alpha, encodes a cytokine with broad inflammatory and immune related functions.

The mutations identified in your TLR and ISG15 genes are compiled and evaluated in order to assign a quality score to your immune system. This quality score varies from 1 star to 5 stars and it is used to determine your odds of resisting infectious diseases.

 

All relevant DNA markers are scanned. We also help you understand what it means for you.

TLR		ISG15
rs1800629 rs361525 rs1799964 rs1800630	rs1799724 rs4248160 rs1800750	rs1921 rs15842 rs2465126 rs2341365 rs1891906	rs1126625 rs3748598 rs60637872 rs60928912 rs55672842

 

Irregularities in your auto-immune system

Your auto-immune system is the first and last line of defense against infectious agents. Our genetic test will identify genetic irregularities and predispositions related to your immune system. Specifically, we test for 6 auto-immune conditions, each transforming the way your immune system responds to diseases. We provide you with the tools you need to understand what it means for you.

Lupus Graves disease Celiac disease

Multiple sclerosis Psoriasis

 

Genetic conditions increasing the severity of influenza

There are also a number of compounding factors into the equation. Heritable factors such as the ones below are examples.

Cardiovascular disease Cardiopulmonary condition

Asthma Cystic fibrosis

 

Wider view of infectious diseases

Our analysis is not limited to influenza. We will look at your general susceptibility for many unrelated infectious diseases, in order to obtain a general assessment of your resistance to pandemics.

 

Innate norovirus resistance Gingivitis HIV resistance Herpes simplex resistance

Hepatitis A and B Susceptibility to SARS Malaria

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